Network pharmacology to uncover potential anti-inflammatory and immunomodulatory constituents in Curcuma longa rhizome as complementary treatment in COVID-19

The immune status of patients plays an essential role in COVID-19. Herbal medicine with immunomodulatory and anti-inflammatory effect could have potential as a complementary therapeutic along modern medicine. This study aims to investigate the constituents Curcuma longa ( C. ) its possible mechanisms We systematically sorted biochemical rhizome from literature repository. Next, we investigated targets related COVID-19 selected active phytochemical analyzed against performed molecular docking four target proteins for further verification. Ten were predicted interact protein targets. epidermal growth factor was most interacted targeted by Calebin A, curcumin, cyclocurcumin, demethoxycurcumin, turmeronol a, b, caffeic acid, quercetin. Interferon-gamma critical 4-hydroxycinnamic acid. Curcumin also toll-like receptor 4 Ar-turmerone angiotensin II type 2. reported signaling pathways associated proteins-active COVID-19: cytokine-cytokine interaction, pathway, Jak-STAT PI3K-Akt pathway. In conclusion, multi compounds might act synergistically affecting inflammatory responses, other pathological processes through multiple pathways.